|Saitama vs. Vaccine Man|
|Outcome||Saitama is victorious|
|Hero Saitama||Villain Vaccine Man|
|Saitama is uninjured||Vaccine Man is killed|
|Previous||Saitama vs. Personification Of A Light Pull Cord|
|Next||Saitama vs. Marugori|
Saitama vs. Vaccine Man is the battle between the hero Saitama and the Dragon level monster Vaccine Man.
Vaccine Man arrives and attacks A-City, using Energy Balls to destroy the nearby buildings. The Hero Association send out Smile Man and Lightning Max, but were easily defeated. Saitama sees the news report and decides to go out to save the day.
Vaccine Man attempts to kill a little girl, but Saitama save the child. Vaccine Man asks for Saitama to identify himself and he does, by saying that he's just an average man acting as an average hero. Vaccine Man is angered by this and aggressively tells the tale of who he is and where he came from. Vaccine Man then began transforming into a giant monstrosity and tells Saitama about his origins. As Vaccine Man is about to attack, Saitama simply punches him killing him.