Saitama vs. Vaccine Man
Location A-City
Chapter(s) 1
Episode(s) 1
Outcome Saitama is victorious
Hero Saitama Villain Vaccine Man
  • Hand-to-Hand combat
Vaccine Man
  • Transformation
Damage Sustained/Casualties
Saitama is uninjured Vaccine Man is killed
Previous Saitama vs. Personification Of A Light Pull Cord
Next Saitama vs. Marugori

Saitama vs. Vaccine Man is the battle between the hero Saitama and the Dragon level monster Vaccine Man.



Lighting Max and Smile Man defeated

Vaccine Man arrives and attacks A-City, using Energy Balls to destroy the nearby buildings. The Hero Association send out Smile Man and Lightning Max, but were easily defeated. Saitama sees the news report and decides to go out to save the day.[1]



Vaccine Man is killed

Vaccine Man attempts to kill a little girl, but Saitama save the child. Vaccine Man asks for Saitama to identify himself and he does, by saying that he's just an average man acting as an average hero. Vaccine Man is angered by this and aggressively tells the tale of who he is and where he came from. Vaccine Man then began transforming into a giant monstrosity and tells Saitama about his origins. As Vaccine Man is about to attack, Saitama simply punches him killing him.[2]


After Saitama defeats him he is seen pounding his fist in anger because of the lack of a challenge he faces. Credit for defeating Vaccine Man went to King who happened to be there at the time.[3]


  1. One-Punch Man Anime; Episode 1
  2. One-Punch Man Manga; Chapter 1, page 1-17
  3. One-Punch Man Manga; Chapter 38, page 3-5